Chapter
LESSONS FROM THE USE OF LITHIUM FOR MANIC DEPRESSION
ENZYME ACTIVITIES IN VIVO
PAYING LIP SERVICE TO ERRORS AND ARTIFACTS, WHILE IGNORING THEM IN CALCULATIONS, CONCLUSIONS AND HYPOTHESES
ANALYSIS OF A TECHNIQUE OR AN ATTACK ON ITS USE
NORMAL HUMAN NEURAL TISSUE
CONTROL EXPERIMENTS IN GENERAL
Chapter 2 Metabolic and functional studies on post-mortem human brain
STUDIES ON METABOLISM IN POST-MORTEM TISSUE
TRANSMITTER UPTAKE, SYNTHESIS AND RELEASE BY POST- MORTEM TISSUE PREPARATIONS
THE UNDERLYING ENZYMIC AND STRUCTURAL INTEGRITY OF POST-MORTEM BRAIN
STORAGE OF TISSUE WITH RETENTION OF ACTIVITY
PROBLEMS ENCOUNTERED WITH THE USE OF HUMAN BRAIN TISSUE FOR BIOCHEMICAL RESEARCH
CONCLUSIONS AND FUTURE PROSPECTS
NEUROTRANSMITTERS STUDIES
MOLECULAR BIOLOGICAL STUDIES
Chapter 3 Communication between neurones: current concepts
THE CONCEPT OF NEUROTRANSMISSION
CAN NEUROTRANSMITTERS BE RELEASED NON-SYNAPTICALLY?
DO NEURONES USE MORE THAN ONE NEUROTRANSMITTER?
CO-EXISTENCE OF TRANSMITTER MOLECULES IN INVERTEBRATE NEURONES
CO-EXISTENCE OF TRANSMITTER MOLECULES IN VERTEBRATE NEURONES
WHY SHOULD A NEURONE NOT CONTAIN MORE THAN ONE TRANSMITTER?
THE CONCEPT OF NEUROMODULATOR?
CRITIQUE CHEMICAL COMMUNICATION BETWEEN NEURONES: THE SIGNIFICANCE OF TEMPORAL PATTERNING
Chapter 4 Possible mechanisms involved in the release and modulation of release of neuroactive agents
THE VESICULAR-EXOCYTOTIC THEORY
THE PHOSPHATIDYLINOSITOL EFFECT
PROTEIN CARBOXYMETHYLATION
CRITIQUE PHYSIOLOGICAL ROLE OF CYTOPLASMIC AND NON-SYNAPTIC RELEASE OF TRANSMITTER
PHYSIOLOGICAL ROLE OF CYTOPLASMIC RELEASE OF TRANSMITTERS
ROLE OF CALCIUM IN RELEASE
Chapter 5 Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase
PREPARATION OF ChAT ANTIGEN AND ANTIChAT ANTIBODIES
DISTRIBUTION OF ChAT IMMUNOREACTIVITY IN THE CNS
THE RELATIONSHIP BETWEEN ChAT AND AChE LOCALIZATION
CRITIQUE ON THE MAPPING OF THE CHOLINERGIC NEURONS BY IMMUNOCYTOCHEMISTRY
Chapter 6 Neural control of muscle
These topics have been discussed in Mayer and Max (1983) and Max and Mayer (1983).
GLUCOSE 6-PHOSPHATE DEHYDROGENASE (G6PD)
Chapter 7 Neurochemical aspects of the opioid-induced 'catatonia'
FROM NEUROCHEMISTRY TO MOTOR PHENOMENA AND BEHAVIOUR
CRITIQUE NEUROCHEMICAL ASPECTS OF THE OPIOID-INDUCED 'CATATONIA'
Chapter 8 Polyamine metabolism and function in brain
POLYAMINE BIOSYNTHESIS AND CATABOLISM
TRANSFORMATION OF PUTRESCINE INTO GABA
POLYAMINES IN MATUR EVERTEBRATE BRAINS
POLYAMINES AND BRAIN DEVELOPMENT
PHARMACOLOGICAL PROPERTIES
MODULATION OF POLYAMINE METABOLISM
CRITIQUE POLYAMINE METABOLISM AND FUNCTION IN BRAIN
Chapter 9 Current status of the biogenic amine theory of depression
1. ASSESSMENT OF THE CLINICAL EVIDENCE
2. ASSESSMENT OF THE PHARMACOLOGICAL EVIDENCE
3. POSSIBLE ROLE OF HISTAMINES, TRACE AMINES AND OTHER SUBSTANCES IN DEPRESSION
CRITIQUE CURRENT STATUS OF THE BIOGENIC AMINE THEORY OF DEPRESSION
Chapter 10 GABA and endocrine regulation—relation to neurologic-psychiatric disorders
PRESENCE OF THE GABA SYSTEM IN ENDOCRINE TISSUES
EFFECTS OF GABA ON HORMONAL RELEASE
RELATION OF GABA TO AN ENDOCRINOLOGICAL BASIS FOR NEUROLOGIC-PSYCHIATRIC DISORDERS OF MAN
CRITIQUE GABA AND ENDOCRINE REGULATION
CRITIQUE OF THE INVOLVEMENT OF GABA IN ENDOCRINE REGULATION
CRITIQUE OF THE ROLE OF GABA IN PSYCHIATRIC DISORDERS
CRITIQUE GABA AND ENDOCRINE REGULATION—RELATION TO NEUROLOGIC-PSYCHIATRIC DISORDERS
Chapter 11 Central GABA-ergic systems and feeding behavior
EFFECTS OF SYSTEMIC ADMINISTRATION OF GABA-ERGIC AGENTS ON FOOD INTAKE
EFFECTS OF INTRACEREBRAL OR INTRACEREBROVENTRICULAR ADMINISTRATION OF GABA-ERGIC AGENTS ON FOOD INTAKE
INTERACTION OF BENZODIAZEPINES AND GABA
EFFECTS OF DIETARY GABA ON FOOD INTAKE AND BODY GROWTH
Chapter 12 GAB A and "Neuro-cardiovascular" mechanisms
1. EFFECTS OF GABA, GABA-ANALOGUES, AND GABA-ANTAGONISTS ON CARDIOVASCULAR FUNCTION
2.THE POSSIBLE ROLE OF THEPERIPHERAL GABA-ERGICSY STEM IN CARDIOVASCULAR CONTROL
3. GABA-RECEPTORS OF BLOOD VESSELS
4.POSSIBLE RELATIONSHIPS BETWEEN
CARDIOVASCULAR GABA-ERGIC MECHANISMS AND HUMAN DISORDERS; CONCLUSIONS AND THEORETICAL CONSIDERATIONS
Chapter 13 Effects of psychoactive agents on GABA binding processes
BENZODIAZEPINE/GABA INTERACTIONS
BARBITURATE/GABA INTERACTIONS
ETHANOL/GABA INTERACTIONS
EFFECTS OF OTHER CENTRALLY-ACTIVE AGENTS ON GABA BINDING
Chapter 14 Do different populations of GABA-receptors exist in the vertebrate CNS?
NA + -DEPENDENT VS NA + -INDEPENDENT GABA BINDING PROCESSES—UPTAKE SITES VS RECEPTOR SITES
EVIDENCE FOR DIFFERENT POPULATIONS OF GABA-RECEPTORS
DERIVED FROM KINETI CANALYSES
OF BINDING DATA
SOLUBILIZED GABA-RECEPTORS:
ONE OR TWO SITES?
EVIDENCE FOR DIFFERENT POPULATIONS OF GABA-RECEPTORS DERIVED FROM HEAT-INACTIVATION STUDIES
EVIDENCE FOR DIFFERENT POPULATIONS OF GABA-RECEPTORS DERIVED FROM STUDIES ON BENZODIAZEPINE-GABA INTERACTIONS
OTHER EVIDENCE FOR DIFFERENT POPULATIONS OF GABA-RECEPTORS BASED ON STUDIES WITH PSYCHOACTIVE DRUGS
PRESYNAPTIC GABA-RECEPTORS
DIFFERENT POPULATIONS OF GABA-RECEPTORS REVEALED BY STUDIES OF FUNCTIONAL AND PHARMACOLOGICAL PROPERTIES
DIFFERENT POPULATIONS OF GABA RECEPTORS REVEALED BY ELECTROPHYSIOLOGICAL STUDIES ON INVERTEBRATE MUSCLE FIBERS
EVIDENCE FOR DIFFERENT POPULATIONS OF GABA-RECEPTORS DERIVED FROM BEHAVIORAL STUDIES
DIFFERENT POPULATIONS OF GABARECEPTORS REVEALED BY ELECTROPHYSIOLOGICAL STUDIES ON INVERTEBRATE MUSCLE FIBERS
EVIDENCE FOR DIFFERENT
POPULATIONS OF GABA-RECEPTORS
DERIVED FROM BEHAVIORAL STUDIES
Chapter 15 Adenosine binding sites in brain; relationship to endogenous levels of adenosine and to its physiological and regulatory roles
ENDOGENOUS LEVELS OF TOTAL AND BOUND ADENOSINE IN BRAIN
CHARACTERISATION OF THE ADENOSINE BINDING SITE
RELATIONSHIP OF S-ADENOSYL HOMOCYSTEINASE TO CYCLIC AMP FORMATION
ENDOGENOUS LEVELS OF TOTAL AND BOUND ADENOSINE IN BRAIN
CHARACTERISATION OF THE ADENOSINE BINDING SITE
RELATIONSHIP OF S-ADENOSYL HOMOCYSTEINASE TO CYCLIC AMP FORMATION
Chapter 16 Photoaffinity labeling of benzodiazepine-receptors: possible mechanism of reaction
Chapter 17 Searching for endogenous ligand(s) of central benzodiazepine receptors
METHODOLOGICAL CONSIDERATIONS
HIGH MOLECULAR WEIGHT COMPOUNDS
LOW MOLECULAR WEIGHT COMPOUNDS
CRITIQUE ENDOGENOUS LIGAND(S) OF BENZODIAZEPINE RECEPTORS?
THE PRESENT STATUS OF DBI ('DIAZEPAM BINDING INHIBITOR')
PUTATIVE ENDOGENOUS LIGANDS IN THE 'LOW MOLECULAR WEIGHT' SERIES
Chapter 18 Neurochemical and neuropharmacological aspects of histamine receptors
REGULATION OF HISTAMINE Hl RECEPTORS
CRITIQUE NEUROCHEMICAL AND NEUROPHARMACOLOGICAL ASPECTS OF HISTAMINE RECEPTORS
Chapter 19 Neurotransmitter-controlled steroid hormone receptors in the central nervous system
CONTROL BY SYMPATHETIC NERVES OF RECEPTORS, METABOLISM AND BIOLOGICAL ACTIVITY OF STEROIDS IN THE PINEAL GLAND
NEUROTRANSMITTER-MEDIATED CONTROL
OF STEROID RECEPTORS AND
ACTIONINTHECNSAND aTHE
ADENOHYPOPHYSIS
Chapter 20 The transduction of environmental lighting cues into biochemical rhythms via mammalian pineal gland
Chapter 21 Biopterin cofactor and monoamine-synthesizing monooxygenases
BIOSYNTHESIS OF MONOAMINES AND THE TETRAHYDROBIOPTERIN COFACTOR
STRUCTURE ACTIVITY RELATIONSHIP OF TETRAHYDROPTERINS AS THE COFACTOR OF PTERIN-REQUIRING MONOOXYGENASES
REGULATION OF PTERIN-REQUIRING MONOOXYGENASES BY PHOSPHORYLATION IN RELATION TO THE PTERIN COFACTOR
REGULATION OF PTERIN-REQUIRING MONOOXYGENASES BY THE BIOPTERIN COFACTOR
REGULATION OF THE BIOSYNTHESIS OF
THE BIOPTERINCOFA CTORBYMONOAMINES
BIOSYNTHESIS OF THE BIOPTERIN COFACTOR
REGULATION OF THE BIOSYNTHESIS OF THE BIOPTERIN COFACTOR BY MONOAMINES
CLINICAL BIOCHEMISTRY OF THE BIOPTERIN COFACTOR
Chapter 22 Regulation and function of pyridoxal phosphate in CNS
METABOLISM OF PYRIDOXAL PHOSPHATE IN BRAIN
DISTRIBUTION OF PYRIDOXAL PHOSPHATE IN BRAIN
REGULATION OF THESYNTHESIS OF
PYRIDOXAL PHOSPHATE IN BRAIN
MODULATION OF SYNTHESIS OF BIOGENIC AMINES BY PYRIDOXAL PHOSPHATE
MODULATION OF SYNTHESIS OF PYRIDOXAL PHOSPHATE BY BIOGENIC AMINES
LEVODOPA, PYRIDOXINE AND TETRAHYDROISOQUINOLINES
PYRIDOXAL PHOSPHATE AND HORMONES
PYRIDOXINE-RELATED SEIZURES
GABA, PYRIDOXAL PHOSPHATE AND SEIZURES
PYRIDOXAL PHOSPHATE AND GABA
RECEPTORS
Chapter 22a. CRITIQUE REGULATION AND FUNCTION OF PYRIDOXAL PHOSPHATE IN CNS
THE METABOLISM AND DISTRIBUTION OF PYRIDOXAL PHOSPHATE
PYRIDOXAL PHOSPHATE AND RECEPTORS
THE REQUIREMENT OF PYRIDOXAL PHOSPHATE BY MULTIPLE FORMS OF GLUTAMIC ACID DECARBOXYLASE
BINDING SITES FOR PYRIDOXAL PHOSPHATE AND ATP ON GLUTAMIC ACID DECARBOXYLASE
THE INTERACTION AMONG ATP, PYRIDOXAL PHOSPHATE, AND GLUTAMIC ACID DECARBOXYLASE
THE INTERACTION AMONG ZINC, ZINC-BINDING PROTEIN, PYRIDOXAL PHOSPHATE, GLUTAMIC ACID DECARBOXYLASE, AND GABA RECEPTOR SITES
PYRIDOXINE-DEPENDENT SEIZURES
THE INDUCEMENT OF CONVULSIVE SEIZURES BY VITAMIN B6 EXCESS
PYRIDOXINE DEFICIENCY AND NEUROTRANSMITTERS
PYRIDOXAL PHOSPHATE IN SEIZURE-PRONE ANIMALS
PYRIDOXAL PHOSPHATE IN THE ZINC-INDUCED INHIBITION OF HIPPOCAMPAL GLUTAMIC ACID DECARBOXYLASE
PYRIDOXINE IN PATIENTS WITH CARPAL TUNNEL SYNDROME
SENSORY NEUROPATHY FROM MEGADOSES OF PYRIDOXINE
Chapter 23 Neurotransmitter function in thiamine-deficiency encephalopathy
SELECTIVE VULNERABILITY OF THE CNS IN THIAMINE DEFICIENCY
CRITIQUE
NEUROTRANSMITTER FUNCTION IN THIAMINE-
DEFICIENCY ENCEPHALOPATHY
THIAMINE-DEPENDENT ENZYMES AND SELECTIVE VULNERABILITY
Chapter 24. B vitamins in the nervous system
METABOLIC FUNCTIONS OF THE B VITAMINS
BLOOD-BRAIN BARRIER TRANSPORT OF VITAMINS
VITAMIN DEFICIENCY AND PSYCHIATRIC ILLNESS
FOLIC ACID AND VITAMIN BI2
CRITIQUE
B VITAMINS IN THE NERVOUS SYSTEM
Chapter 25 Glycoproteins associated with myelin in the central nervous system
IDENTIFICATION AND CHARACTERIZATION
PURIFICATION AND IMMUNOGENICS
Chapter 26 Gangliosides in the nervous system
CLASSIFICATION OF GANGLIOSIDES FOUND IN THE NERVOUS SYSTEM
ADVANCES IN ISOLATION AND
ANALYTICAL METHODS
IMPROVED METHODOLOGY FOR STRUCTURAL ANALYSIS OF GANGLIOSIDES
DISTRIBUTION OF GANGLIOSIDES IN THE NERVOUS SYSTEM
BIOSYNTHESIS OF GANGLIOSIDES
DEGRADATION AND TURNOVER OF GANGLIOSIDES
GANGLIOSIDE COMPOSITIONAL
CHANGES WITH DEVELOPMENT AND
AGING, AND CELL DIFFERENTIATION
ALTERATIONS IN MEMBRANE GANGLIOSIDES DUE TO TRANSFORMATION
POSSIBLE BIOLOGICAL FUNCTIONS OF GANGLIOSIDES
CRITIQUE GANGLIOSIDES IN THE NERVOUS SYSTEM
CRITIQUE
FUNCTIONAL IMPLICATION OF GANGLIOSIDES
IN SYNAPTIC TRANSMISSION
MAY GANGLIOSIDES ACT AS MODULATOR SUBSTANCES FOR SYNAPTIC TRANSMISSION?
Chapter 27 Tubulin in the nervous system
DEVELOPMENTAL SPECIFICITY
THE GENETIC CONTROL OF
TUBULIN EXPRESSION
MICROTUBULE FUNCTION IN THE NERVOUS SYSTEM: AXONAL GROWTH AND AXOPLASMIC TRANSPORT
CRITIQUE TUBULIN IN THE NERVOUS SYSTEM
CRITIQUE TUBULIN IN THE NERVOUS SYSTEM
Chapter 28. Calmodulin-binding proteins in brain
1. A HEAT-LABILE PHOSPHODIESTERASE INHIBITOR PROTEIN: CALCINEURIN
2.A HEAT-STABLE 70K CALMODULIN-BINDING PROTEIN
3.A 50 K CALMODULIN-BINDING PROTEIN
4. MYELIN BASIC PROTEIN AS A CALMODULIN-BINDING PROTEIN
5. ASSOCIATION OF CALMODULIN WITH COATED VESICLES
6. CALMODULIN-BINDING PROTEINS OF BRAIN MICROTUBULES
7. A SPECTRIN-LIKE CALMODULIN-BINDING PROTEIN
8.A 155 K PARTICLE-ASSOCIATED CALMODULIN-BINDING PROTEIN
9.PARTICLE-BOUND AND EGTA-NONEXTRACTABLE FORM OF CALMODULIN
Selected Topics from Neurochemistry
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