Publisher: John Wiley & Sons Inc
E-ISSN: 1521-3765|21|50|18068-18071
ISSN: 0947-6539
Source: CHEMISTRY - A EUROPEAN JOURNAL, Vol.21, Iss.50, 2015-12, pp. : 18068-18071
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
AbstractA rapid route to 5,5‐ and 5,6‐ bicyclic systems is provided by an 1,3‐alkyl‐shift process mediated by a hypervalent iodine reagent on aromatics. The structures obtained contain several unsaturations with different behaviors and reactivities. Such diversity allows further elaborations for the rapid formation of compact systems present in a variety of natural products. The potential for further transformations has been demonstrated by performing a double Michael addition. This cyclization process is regio‐ and stereoselective due to the presence of a former benzylic substituent. Furthermore, an extension of this approach has been accomplished on indole derivatives.
Related content
Natural Products in Drug Discovery
By Roggo Silvio
CHIMIA International Journal for Chemistry, Vol. 61, Iss. 6, 2007-06 ,pp. :
Natural Products in Crop Protection
CHIMIA International Journal for Chemistry, Vol. 52, Iss. 1-2, 1998-01 ,pp. :