(+)‐1‐[(R)‐3,3,3‐Trifluoro‐2‐meth­oxy‐2‐phenyl­propion­yl]‐4‐(4‐{[(2R,4S)‐2‐(2,4‐dichloro­phen­yl)‐2‐(1H‐imidazol‐1‐ylmeth­yl)‐1,3‐dioxolan‐4‐yl]meth­oxy}phen­yl)piperazine methanol solvate

Publisher： John Wiley & Sons Inc

E-ISSN： 1600-5368|62|1|o191-o192

ISSN： 1600-5368

Source： Acta Crystallographica Section E, Vol.62, Iss.1, 2006-01, pp. : o191-o192

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Abstract

The crystal structure and absolute configuration of the title compound, C34H33Cl2F3N4O5·CH4O, were determined to examine the validity of van 't Hoff's principle of additivity of optical rotations. The conformation of the dioxolane ring is halfway between an envelope, with the flap at the unsubstituted C atom, and a form twisted about Cmethyl­ene—O. The methanol mol­ecule is hydrogen bonded via the OH group to the unsubstituted N atom of the imidazole group.

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