Vitamin E and hepatotoxic agents

Publisher： Cambridge University Press

E-ISSN： 1475-2662|24|2|357-384

ISSN： 0007-1145

Source： British Journal of Nutrition, Vol.24, Iss.2, 1970-06, pp. : 357-384

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Abstract

1. The acute toxicity of orally administered CCl4 and its subacute toxicity (liver necrosis and hepatic fat accumulation) were studied in young adult male and female rats. CCl4 was more toxic in males than in females. The protective effects of vitamin E (D-α-tocopheryl acetate) and three synthetic antioxidants, DPPD (N,N'-diphenyl-p-phenylenediamine), ethoxyquin (6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline) and BHT (butylated hydroxytoluene) were studied.

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