Cross‐reactivity between voriconazole, fluconazole and itraconazole

Publisher： John Wiley & Sons Inc

E-ISSN： 1365-2710|41|5|566-567

ISSN： 0269-4727

Source： JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Vol.41, Iss.5, 2016-10, pp. : 566-567

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Abstract

Summary

What is known and objectiveHypersensitivity to triazoles is a rare occurrence and cross‐reactivity between agents is unknown. We present a successful voriconazole challenge in a patient allergic to fluconazole and itraconazole.
Case summaryA 41‐year‐old immunocompetent male with coccidioidomycosis developed fever, eosinophilia and maculopapular rash from fluconazole. Switching to itraconazole resulted in worsening of the rash and skin sloughing over 25% of his body. He was given an oral‐graded challenge of voriconazole which he tolerated without incident.
What is new and conclusionThis is the first report of a lack of cross‐reactivity between itraconazole and voriconazole.

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