Synthesis and biological evaluation of novel lignan glycosides as anticancer agents

Publisher: John Wiley & Sons Inc

E-ISSN: 1747-0285|88|4|562-567

ISSN: 1747-0277

Source: CHEMICAL BIOLOGY & DRUG DESIGN (ELECTRONIC), Vol.88, Iss.4, 2016-10, pp. : 562-567

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Abstract

Novel lignan glycosides 1a–1 h as analogues of cleistanthin A were designed and synthesized. Most of these compounds displayed significant cytotoxicities against four cancer cell lines. Compound 1e displayed better cytotoxicity than cleistanthin A with IC50 values from 1.0 nm to 8.3 nm. Further lysosome acidity assay disclosed that 1e could totally inhibit the activity of V‐ATPase at 60 nm.

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