4´-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

Author: de Campos-Buzzi Fátima   Padaratz Pâmela   Meira Aleandra Vergilina   Corrêa Rogério   Nunes Ricardo José   Cechinel-Filho Valdir  

Publisher: MDPI

E-ISSN: 1420-3049|12|4|896-906

ISSN: 1420-3049

Source: Molecules, Vol.12, Iss.4, 2007-04, pp. : 896-906

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Abstract

Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs.

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