Author： Lin Jieru E. Valentino Michael Marszalowicz Glen Magee Michael S. Li Peng Snook Adam E. Stoecker Brian A. Chang Chang Waldman Scott A.
Publisher： MDPI
E-ISSN： 2072-6651|2|8|2028-2054
ISSN： 2072-6651
Source： Toxins, Vol.2, Iss.8, 2010-08, pp. : 2028-2054
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Abstract
Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer.
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