Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum

Author： Yu Ke Ren Biao Wei Junli Chen Caixia Sun Jinsheng Song Fuhang Dai Huanqin Zhang Lixin

Publisher： MDPI

E-ISSN： 1660-3397|8|11|2744-2754

ISSN： 1660-3397

Source： Marine Drugs, Vol.8, Iss.11, 2010-11, pp. : 2744-2754

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Abstract

The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.