Author: Bao Pingping Zhang Xiaole Ren Hong Li Yan Mu Zulin Zhang Shuwei Li Guohui Yang Ling
Publisher: MDPI
E-ISSN: 1422-0067|12|12|8961-8981
ISSN: 1422-0067
Source: International Journal of Molecular Sciences, Vol.12, Iss.12, 2011-12, pp. : 8961-8981
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The nociceptin/orphanin FQ (NOP) receptor is involved in a wide range of biological functions, including pain, anxiety, depression and drug abuse. Especially, its agonists have great potential to be developed into anxiolytics. In this work, both the ligand- and receptor-based three-dimensional quantitative structure–activity relationship (3D-QSAR) studies were carried out using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques on 103 N-substituted spiropiperidine analogues as NOP agonists. The resultant optimal ligand-based CoMSIA model exhibited
Related content
By Chianese Giuseppina Scala Fernando Calcinai Barbara Cerrano Carlo Dien Henny A. Kaiser Marcel Tasdemir Deniz Taglialatela-Scafati Orazio
Marine Drugs, Vol. 11, Iss. 9, 2013-08 ,pp. :
New MT2 Melatonin Receptor-Selective Ligands: Agonists and Partial Agonists
By Boutin Jean A. Bonnaud Anne Brasseur Chantal Bruno Olivier Lepretre Nolwenn Oosting Peter Coumailleau Sophie Delagrange Philippe Nosjean Olivier Legros Céline
International Journal of Molecular Sciences, Vol. 18, Iss. 7, 2017-06 ,pp. :