Author： Stolfi Carmine Pallone Francesco Monteleone Giovanni
Publisher： MDPI
E-ISSN： 1422-0067|13|7|7886-7901
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.13, Iss.7, 2012-06, pp. : 7886-7901
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily, interacts with its functional death receptors (DRs) and induces apoptosis in a wide range of cancer cell types. Therefore, TRAIL has been considered as an attractive agent for cancer therapy. However, many cancers are resistant to TRAIL-based therapies mainly due to the reduced expression of DRs and/or up-regulation of TRAIL pathway-related anti-apoptotic proteins. Compounds that revert such defects restore the sensitivity of cancer cells to TRAIL, suggesting that combined therapies could help manage neoplastic patients. In this article, we will focus on the TRAIL-sensitizing effects of natural products and synthetic compounds in colorectal cancer (CRC) cells and discuss the molecular mechanisms by which such agents enhance the response of CRC cells to TRAIL.
Related content
Potential Targets for Colorectal Cancer Prevention
By Temraz Sally Mukherji Deborah Shamseddine Ali
International Journal of Molecular Sciences, Vol. 14, Iss. 9, 2013-08 ,pp. :
Access to resources
Recommend
Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer
By Chang Chu-Cheng Lin Pei-Ching Lin Chun-Chi Lan Yuan-Tzu Lin Hung-Hsin Lin Chien-Hsing Yang Shung-Haur Liang Wen-Yi Chen Wei-Shone Jiang Jeng-Kai Lin Jen-Kou Chang Shih-Ching
International Journal of Molecular Sciences, Vol. 18, Iss. 7, 2017-07 ,pp. :
TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy
By Farooqi Ammad Ahmad Shu Chih-Wen Huang Hurng-Wern Wang Hui-Ru Chang Yung-Ting Fayyaz Sundas Yuan Shyng-Shiou F. Tang Jen-Yang Chang Hsueh-Wei
International Journal of Molecular Sciences, Vol. 18, Iss. 7, 2017-07 ,pp. :