Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat

Author： Luo Bin Zhang Shuyu Ma Shoucun Zhou Ji Wang Baojian

Publisher： MDPI

E-ISSN： 1660-4601|9|7|2312-2325

ISSN： 1660-4601

Source： International Journal of Environmental Research and Public Health, Vol.9, Iss.7, 2012-06, pp. : 2312-2325

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Abstract

The purpose of this study is to explore possible potential implications of cold air in cardiovascular disease (CVD) risk in rats. Healthy Wistar rats were exposed to artificial cold air under laboratory conditions, and their systolic blood pressure, heart rate, vasoconstriction, CVD risk factors, and myocardial damage indicators after cold air exposure were determined and evaluated. Systolic blood pressure, whole blood viscosity, and plasma level of norepinephrine, angiotensinⅡ, low density lipoprotein, total cholesterol, and fibrinogen in treatment groups increased significantly compared with control groups. No significant variations were found in plasma Mb and cTnT and myocardial tissue between the treatment and control groups. Results indicate that: (1) higher levels of SBP, WBV and LDL/HDL, total cholesterol (TC), and FG in blood may indicate higher CVD risks during cold air exposure; (2) cold air may exert continuous impacts on SBP and other CVD risk factors.