Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

Author: Menna Marialuisa   Aiello Anna   D’Aniello Filomena   Fattorusso Ernesto   Imperatore Concetta   Luciano Paolo   Vitalone Rocco  

Publisher: MDPI

E-ISSN: 1660-3397|10|11|2509-2518

ISSN: 1660-3397

Source: Marine Drugs, Vol.10, Iss.11, 2012-11, pp. : 2509-2518

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Abstract

An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.

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