Two New Phenolic Glycosides from Gnaphalium affine D. Don and Their Anti-Complementary Activity

Author： Li Junli   Huang Doudou   Chen Wansheng   Xi Zhongxin   Chen Cheng   Huang Guanghui   Sun Lianna  

Publisher： MDPI

E-ISSN： 1420-3049|18|7|7751-7760

ISSN： 1420-3049

Source： Molecules, Vol.18, Iss.7, 2013-07, pp. : 7751-7760

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Abstract

Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-d-glucopyranoside (5), quercetin-3-O-β-d-glucopyranoside (6), scutellarein-7-O-β-d-glucoside (7) and api-genin-7-O-β-d-glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.

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