Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Author： Mabkhot Yahia Nasser   Kheder Nabila Abdelshafy   Farag Ahmad M.  

Publisher： MDPI

E-ISSN： 1420-3049|18|4|4669-4678

ISSN： 1420-3049

Source： Molecules, Vol.18, Iss.4, 2013-04, pp. : 4669-4678

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Abstract

A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin Bagainst Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.

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