Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats

Author： Lim Dong Wook Kim Yun Tai Jang Yu-Jung Kim Young-Eon Han Daeseok

Publisher： MDPI

E-ISSN： 1420-3049|18|8|9241-9252

ISSN： 1420-3049

Source： Molecules, Vol.18, Iss.8, 2013-08, pp. : 9241-9252

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Abstract

This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.