Consequences of Morphology on Molecularly Imprinted Polymer-Ligand Recognition

Author： Rosengren Annika M.   Karlsson Björn C. G.   Nicholls Ian A.  

Publisher： MDPI

E-ISSN： 1422-0067|14|1|1207-1217

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.14, Iss.1, 2013-01, pp. : 1207-1217

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Abstract

The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (~3–4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant mesoand macropore size distributions.

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