Author： Monico Carina Capitanio Marco Belcastro Gionata Vanzi Francesco Pavone Francesco S.
Publisher： MDPI
E-ISSN： 1422-0067|14|2|3961-3992
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.14, Iss.2, 2013-02, pp. : 3961-3992
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Abstract
The maintenance of intact genetic information, as well as the deployment of transcription for specific sets of genes, critically rely on a family of proteins interacting with DNA and recognizing specific sequences or features. The mechanisms by which these proteins search for target DNA are the subject of intense investigations employing a variety of methods in biology. A large interest in these processes stems from the faster-than-diffusion association rates, explained in current models by a combination of 3D and 1D diffusion. Here, we present a review of the single-molecule approaches at the forefront of the study of protein-DNA interaction dynamics and target search
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