Author: Dawson Sarah H. Arnold Nadine D. Pickworth Josephine A. Francis Sheila E. Lawrie Allan
Publisher: MDPI
E-ISSN: 2079-9721|2|3|260-273
ISSN: 2079-9721
Source: Diseases, Vol.2, Iss.3, 2014-07, pp. : 260-273
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Abstract
Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulmonary arterial blood pressure that is driven by a progressive vascular remodelling of small pulmonary arterioles. We have previously reported that tumor necrosis factor apoptosis-inducing ligand (TRAIL) protein expression is increased in pulmonary vascular lesions and pulmonary artery smooth muscle cells (PASMC) of patients with idiopathic PAH. The addition of recombinant TRAIL induces the proliferation and migration of PASMCs
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