Author： Geier David A. Hooker Brian S. Kern Janet K. King Paul G. Sykes Lisa K. Geier Mark R.
Publisher： MDPI
E-ISSN： 1660-4601|11|9|9156-9170
ISSN： 1660-4601
Source： International Journal of Environmental Research and Public Health, Vol.11, Iss.9, 2014-09, pp. : 9156-9170
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
A hypothesis testing case-control study evaluated concerns about the toxic effects of organic-mercury (Hg) exposure from thimerosal-containing (49.55% Hg by weight) vaccines on the risk of neurodevelopmental disorders (NDs). Automated medical records were examined to identify cases and controls enrolled from their date-of-birth (1991–2000) in the Vaccine Safety Datalink (VSD) project. ND cases were diagnosed with pervasive developmental disorder (PDD), specific developmental delay, tic disorder or hyperkinetic syndrome of childhood. In addition, putative non-thimerosal-related outcomes of febrile seizure, failure to thrive and cerebral degenerations were examined. The cumulative total dose of Hg exposure from thimerosal-containing hepatitis B vaccine (T-HBV) administered within the first six months of life was calculated. On a per microgram of organic-Hg basis, PDD (odds ratio (OR) = 1.054), specific developmental delay (OR = 1.035), tic disorder (OR = 1.034) and hyperkinetic syndrome of childhood (OR = 1.05) cases were significantly more likely than controls to receive increased organic-Hg exposure. By contrast, none of the non-thimerosal related outcomes were significantly more likely than the controls to have received increased organic-Hg exposure. Routine childhood vaccination may be an important public health tool to reduce infectious disease-associated morbidity/mortality, but the present study significantly associates organic-Hg exposure from T-HBV with an increased risk of an ND diagnosis.
Related content
By Wu Yue Gu Jun-Ming Huang Yun Duan Yan-Ying Huang Rui-Xue Hu Jian-An
International Journal of Environmental Research and Public Health, Vol. 13, Iss. 3, 2016-03 ,pp. :
Access to resources
Recommend
By Marushka Lesya Hu Xuefeng Batal Malek Sadik Tonio Schwartz Harold Ing Amy Fediuk Karen Tikhonov Constantine Chan Hing Man
International Journal of Environmental Research and Public Health, Vol. 15, Iss. 3, 2018-03 ,pp. :
By Heavner Karyn Newschaffer Craig Hertz-Picciotto Irva Bennett Deborah Burstyn Igor
International Journal of Environmental Research and Public Health, Vol. 12, Iss. 11, 2015-11 ,pp. :