Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Author： Rahbar Mohammad H.   Samms-Vaughan Maureen   Ma Jianzhong   Bressler Jan   Loveland Katherine A.   Ardjomand-Hessabi Manouchehr   Dickerson Aisha S.   Grove Megan L.   Shakespeare-Pellington Sydonnie   Beecher Compton   McLaughlin Wayne   Boerwinkle Eric  

Publisher： MDPI

E-ISSN： 1660-4601|11|8|7874-7895

ISSN： 1660-4601

Source： International Journal of Environmental Research and Public Health, Vol.11, Iss.8, 2014-08, pp. : 7874-7895

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Abstract

Arsenic is a toxic metalloid with known adverse effects on human health. Glutathione-S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play a major role in detoxification and metabolism of xenobiotics. We investigated the association between GST genotypes and whole blood arsenic concentrations (BASC) in Jamaican children with and without autism spectrum disorder (ASD). We used data from 100 ASD cases and their 1:1 age- and sex-matched typically developing (TD) controls (age 2–8 years) from Jamaica. Using log-transformed BASC as the dependent variable in a General Linear Model, we observed a significant interaction between GSTP1 and ASD case status while controlling for several confounding variables. However, for GSTT1 and GSTM1 we did not observe any significant associations with BASC. Our findings indicate that TD children who had the Ile/Ile or Ile/Val genotype for GSTP1 had a significantly higher geometric mean BASC than those with genotype Val/Val (3.67 µg/L vs. 2.69 µg/L, p < 0.01). Although, among the ASD cases, this difference was not statistically significant, the direction of the observed difference was consistent with that of the TD control children. These findings suggest a possible role of GSTP1 in the detoxification of arsenic.

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