Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.

Author： Juan Yung-Shun   Lee Chien-Chih   Tsao Chia-Wei   Lu Mei-Chin   El-Shazly Mohamed   Shih Huei-Chuan   Chen Yu-Cheng   Wu Yang-Chang   Su Jui-Hsin  

Publisher： MDPI

E-ISSN： 1422-0067|15|9|16511-16521

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.15, Iss.9, 2014-09, pp. : 16511-16521

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Abstract

The sponge Petrosia sp. yielded five polyacetylenic compounds (1–5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1–5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.

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