Author： Mérour Jean-Yves Buron Frédéric Plé Karen Bonnet Pascal Routier Sylvain
Publisher： MDPI
E-ISSN： 1420-3049|19|12|19935-19979
ISSN： 1420-3049
Source： Molecules, Vol.19, Iss.12, 2014-11, pp. : 19935-19979
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Abstract
This review article illustrates the growing use of azaindole derivatives as kinase inhibitors and their contribution to drug discovery and innovation. The different protein kinases which have served as targets and the known molecules which have emerged from medicinal chemistry and Fragment-Based Drug Discovery (FBDD) programs are presented. The various synthetic routes used to access these compounds and the chemical pathways leading to their synthesis are also discussed. An analysis of their mode of binding based on X-ray crystallography data gives structural insights for the design of more potent and selective inhibitors.
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