Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems

Author： Jiang Feng Liu Biao Lu Jun Li Fangfei Li Defang Liang Chao Dang Lei Liu Jin He Bing Atik Badshah Shaikh Lu Cheng He Xiaojuan Guo Baosheng Zhang Xiao-Bing Tan Weihong Lu Aiping Zhang Ge

Publisher： MDPI

E-ISSN： 1422-0067|16|10|23784-23822

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.16, Iss.10, 2015-10, pp. : 23784-23822

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.