Author： Ould M’hamed Mohamed Alshammari Abdulrahman G. Lemine O. M.
Publisher： MDPI
E-ISSN： 2076-3417|6|12|431-431
ISSN： 2076-3417
Source： Applied Sciences, Vol.6, Iss.12, 2016-12, pp. : 431-431
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Abstract
A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).
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