Author: Vallacchi Viviana Camisaschi Chiara Dugo Matteo Vergani Elisabetta Deho Paola Gualeni Ambra Huber Veronica Gloghini Annunziata Maurichi Andrea Santinami Mario Sensi Marialuisa Castelli Chiara Rivoltini Licia Rodolfo Monica
Publisher: MDPI
E-ISSN: 2073-4425|7|12|124-124
ISSN: 2073-4425
Source: Genes, Vol.7, Iss.12, 2016-12, pp. : 124-124
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Abstract
Sentinel node biopsy (SNB) is a main staging biomarker in melanoma and is the first lymph node to drain the tumor, thus representing the immunological site where anti-tumor immune dysfunction is established and where potential prognostic immune markers can be identified. Here we analyzed microRNA (miR) profiles in archival tumor-positive SNBs derived from melanoma patients with different outcomes and performed an integrated analysis of transcriptional data to identify deregulated immune signaling networks. Twenty-six miRs were differentially expressed in melanoma-positive SNB samples between patients with disease progression and non-progressing patients, the majority being previously reported in the regulation of immune responses. A significant variation in miR expression levels was confirmed in an independent set of SNB samples. Integrated information from genome-wide transcriptional profiles and in vitro assessment in immune cells led to the identification of miRs associated with the regulation of the TNF receptor superfamily member 8 (
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