Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview

Author: Pompili Maurizio   Baldessarini Ross J.   Forte Alberto   Erbuto Denise   Serafini Gianluca   Fiorillo Andrea   Amore Mario   Girardi Paolo  

Publisher: MDPI

E-ISSN: 1422-0067|17|10|1700-1700

ISSN: 1422-0067

Source: International Journal of Molecular Sciences, Vol.17, Iss.10, 2016-10, pp. : 1700-1700

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Abstract

Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.

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