Author: Pan Guixiang Li Tingting Zeng Qingqing Wang Xiaoming Zhu Yan
Publisher: MDPI
E-ISSN: 1420-3049|21|2|183-183
ISSN: 1420-3049
Source: Molecules, Vol.21, Iss.2, 2016-02, pp. : 183-183
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Multidrug resistance (MDR) is a prime reason for numerous failed oncotherapy approaches. In the present study, we investigated whether Alisol F 24 acetate (ALI) could reverse the MDR of MCF-7/DOX cells, a multidrug-resistant human breast cancer cell line. We found that ALI was a potent P-glycoprotein (P-gp) inhibitor, in the Caco-2-monolayer cell model. ALI showed a significant and concentration-dependent cytotoxic effect on MCF-7/DOX cells in combination with doxorubicin by increasing intracellular accumulation and inducing nuclear migration of doxorubicin. However, ALI had no such effect on MCF-7 cells. In addition, ALI also promoted doxorubicin-induced early apoptosis of MCF-7/DOX cells in a time-dependent manner. These results suggest that ALI can enhance chemosensitivity of doxorubicin and reinforce its anti-cancer effect by increasing its uptake, especially inducing its nuclear accumulation in MCF-7/DOX cells. Therefore, ALI could be developed as a potential MDR-reversing agent in cancer chemotherapy in further study.
Related content
By Šereš Mário Cholujová Dana Bubenčíkova Tatiana Breier Albert Sulová Zdenka
International Journal of Molecular Sciences, Vol. 12, Iss. 11, 2011-11 ,pp. :
By Karimian Hamed Mohan Syam Zorofchian Moghadamtousi Soheil Fadaeinasab Mehran Razavi Mahboubeh Arya Aditya Kamalidehghan Behnam Mohd Ali Hapipah Ibrahim Noordin Mohamad
Molecules, Vol. 19, Iss. 7, 2014-07 ,pp. :
By Abdullah Al-Shwyeh Hussah Mohammed Abdulkarim Sabo Rasedee Abdullah Mirghani Mohamed Elwathig Saeed
International Journal of Molecular Sciences, Vol. 16, Iss. 2, 2015-02 ,pp. :