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Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Author： Zhao Huan Peng Qinghua Han Zhuzhen Yang Li Wang Zhengtao

Publisher： MDPI

E-ISSN： 1420-3049|21|3|281-281

ISSN： 1420-3049

Source： Molecules, Vol.21, Iss.3, 2016-02, pp. : 281-281

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Abstract

Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC₅₀ value of 8.1 μM.

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