Author： Ramassone Alice Pagotto Sara Veronese Angelo Visone Rosa
Publisher： MDPI
E-ISSN： 1422-0067|19|2|459-459
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.19, Iss.2, 2018-02, pp. : 459-459
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Abstract
The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional structure of the genome is exploited by cancer cells to promote tumorigenesis. This reprogramming occurs because of hereditable chromatin chemical modifications and the consequent formation of RNA-protein-DNA complexes that represent the principal actors of the epigenetic phenomena. In this regard, the deregulation of a transcribed non-coding RNA may be both cause and consequence of a cancer-related epigenetic alteration. This review summarizes recent findings that implicate microRNAs in the aberrant epigenetic regulation of cancer cells.
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