Author： Alberti Thaís Barbosa Barbosa Wagner Luiz Ramos Vieira José Luiz Fernandes Raposo Nádia Rezende Barbosa Dutra Rafael Cypriano
Publisher： MDPI
E-ISSN： 1422-0067|18|4|691-691
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.18, Iss.4, 2017-04, pp. : 691-691
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
(−)-β-caryophyllene (BCP), a cannabinoid receptor type 2 (CB2)-selective phytocannabinoid, has already been shown in precedent literature to exhibit both anti-inflammatory and analgesic effects in mouse models of inflammatory and neuropathic pain. Herein, we endeavored to investigate the therapeutic potential of BCP on experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Furthermore, we sought to demonstrate some of the mechanisms that underlie the modulation BCP exerts on autoimmune activated T cells, the pro-inflammatory scenery of the central nervous system (CNS), and demyelination. Our findings demonstrate that BCP significantly ameliorates both the clinical and pathological parameters of EAE. In addition, data hereby presented indicates that mechanisms underlying BCP immunomodulatory effect seems to be linked to its ability to inhibit microglial cells, CD4+ and CD8+ T lymphocytes, as well as protein expression of pro-inflammatory cytokines. Furthermore, it diminished axonal demyelination and modulated Th1/Treg immune balance through the activation of CB2 receptor. Altogether, our study represents significant implications for clinical research and strongly supports the effectiveness of BCP as a novel molecule to target in the development of effective therapeutic agents for MS.
Related content
New MT2 Melatonin Receptor-Selective Ligands: Agonists and Partial Agonists
By Boutin Jean A. Bonnaud Anne Brasseur Chantal Bruno Olivier Lepretre Nolwenn Oosting Peter Coumailleau Sophie Delagrange Philippe Nosjean Olivier Legros Céline
International Journal of Molecular Sciences, Vol. 18, Iss. 7, 2017-06 ,pp. :
Access to resources
Recommend
By Fellner Avi Barhum Yael Angel Ariel Perets Nisim Steiner Israel Offen Daniel Lev Nirit
International Journal of Molecular Sciences, Vol. 18, Iss. 8, 2017-08 ,pp. :
Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy
By Matsubara Ryota Kumagai Kenichi Shigematsu Hiroaki Kitaura Kazutaka Nakasone Yasunari Suzuki Satsuki Hamada Yoshiki Suzuki Ryuji
International Journal of Molecular Sciences, Vol. 18, Iss. 7, 2017-06 ,pp. :
Regulation of an Autoimmune Model for Multiple Sclerosis in Th2-Biased GATA3 Transgenic Mice
By Fernando Viromi Omura Seiichi Sato Fumitaka Kawai Eiichiro Martinez Nicholas E. Elliott Sadie Faith Yoh Keigyou Takahashi Satoru Tsunoda Ikuo
International Journal of Molecular Sciences, Vol. 15, Iss. 2, 2014-01 ,pp. :