

Author: Li Bin Song Zhenquan Liang Guobiao Lei Wei Wang Zhijun Liu Enzhi Li Xiaoming Liu Hongbo
Publisher: Govi-Verlag
ISSN: 0031-7144
Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Vol.70, Iss.4, 2015-04, pp. : 251-255
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Abstract
The potential role of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on rat neuronal apoptosis after diffuse brain injury (DBI) coupled with secondary brain injury (SBI) was investigated. One hundred and twelve adult male Wister rats weighing 305-355 g were randomly divided into four groups and received an intraperitoneal injection of 8-OH-DPAT (0.5 mg/kg) or an equal volume of normal saline. Neurological severity score (NSS) was recorded and the injured extent was observed after hematoxylin-eosin (HE) staining. The neuronal cell apoptosis index and the expression of Bax and Bcl-2 were detected by TUNEL method and immunohistochemistry respectively. We found a higher NSS value for rats in the DBI + SBI groups compared with those in normal control and sham-operated control groups (
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