Palladium‐Catalyzed Amination of Aryl Sulfides with Aliphatic Amines

Publisher: John Wiley & Sons Inc

E-ISSN: 1099-0690|2015|12|2678-2682

ISSN: 1434-193x

Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol.2015, Iss.12, 2015-04, pp. : 2678-2682

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Abstract

AbstractConditions for the palladium–NHC‐catalyzed amination of aryl sulfides with aliphatic as well as aromatic amines were established. The KHMDS‐mediated amination of heteroaryl sulfides could proceed without palladium. Based on the distinct difference in reactivity of C–Br and C–S bonds, a sequential amination of bromothioanisole can take place to install two different alkylamino groups onto the aromatic ring in one pot.