Sensors: Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers (Adv. Funct. Mater. 38/2015)

Publisher: John Wiley & Sons Inc

E-ISSN: 1616-3028|25|38|6147-6147

ISSN: 1616-301x

Source: ADVANCED FUNCTIONAL MATERIALS, Vol.25, Iss.38, 2015-10, pp. : 6147-6147

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Abstract

On page 6050, J. J. de Pablo and co‐workers demonstrate detection of Nanomolar concentrations of peptides by polarized light microscopy. Liquid crystals exhibit a specific response to beta‐sheet structures. The unstructured peptides involved in various diseases form beta‐sheet rich amyloid fibrils at lipid‐decorated liquid crystal interfaces, thereby altering the orientation of the underlying liquid crystal and yielding characteristic optical signatures that are interpreted in terms of detailed molecular models.