Preparation of 6‐Difluoromethylphosphonated Phenanthridines by Visible‐Light‐Driven Radical Cyclization of 2‐Isocyanobiphenyls

Publisher: John Wiley & Sons Inc

E-ISSN: 1099-0690|2015|31|6817-6821

ISSN: 1434-193x

Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol.2015, Iss.31, 2015-11, pp. : 6817-6821

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Abstract

AbstractA protocol to obtain a variety of 6‐difluoromethylenephosphonated phenanthridines through a radical cyclization process was explored. These reactions, performed with the use of diethyl bromodifluoromethylphosphonate as a radical resource and 2‐isocyanobiphenyls as radical acceptors, were smoothly triggered by visible‐light photocatalysis. Electron‐withdrawing and electron‐donating groups were well tolerated, and the target molecules were obtained in excellent to moderate yields.