Treatment of choroid metastasis from lung adenocarcinoma with bevacizumab-containing chemotherapy: A case report

Author： Makabe Kenichi Kurishima Koichi Shiozawa Toshihiro Miyazaki Kunihiko Ohara Gen Kagohashi Katsunori Satoh Hiroaki Hizawa Nobuyuki

Publisher： Spandidos Publications

E-ISSN： 1792-1015|11|1|239-242

ISSN： 1792-0981

Source： Experimental and Therapeutic Medicine, Vol.11, Iss.1, 2016-01, pp. : 239-242

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Abstract

The occurrence of ocular metastasis from lung cancer is uncommon. The present study reports the case of a 69-year-old female patient with lung adenocarcinoma who was found to have a metastatic lesion in the left choroid at the time of presentation. As the patient was found to have a mutation in the epidermal growth factor receptor, treatment with gefitinib was administered; however, the response was evaluated as a progressive disease. Thereafter, the patient received chemotherapy with carboplatin, pemetrexed and bevacizumab. Radiological imaging revealed shrinkage of the primary lesion and choroidal metastasis, and the visual power of the left eye was also shown to improve. Therefore, the present case report demonstrated the efficacy and safety of systemic bevacizumab therapy in combination with a platinum doublet for the treatment of choroid metastasis, with morphological and functional improvements observed with regard to the choroidal metastatic tumor.