Description
3D Printing in Medicine examines the emerging market of 3D-printed biomaterials and its clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field.
The book begins with a discussion of the fundamentals of 3D printing, including topics such as materials, and hardware. Chapters go on to cover applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing and 3D cell and organ printing. The concluding chapters in the book review the applications of 3D printing in diagnostics, drug development, 3D-printed disease models and 3D printers for surgical practice.
With a strong focus on the translation of 3D printing technology to a clinical setting, this book is a valuable resource for scientists and engineers working in biomaterial, biomedical, and nanotechnology based industries and academia.
- Provides a comprehensive and authoritative overview of all the medical applications of 3D printing biomaterials and technologies
- Focuses on the emerging market of 3D printed biomaterials in clinical applications
- Reviews both commercial and under development materials, tools, their applications, and future evolution
Chapter
1.1.1 Brief history of 3D printing
1.1.2 Basic components of 3D printing
1.2 3D bioprinting in medicine
1.2.1 3D bioprinting approaches
1.2.1.2 Independent self-assembly
1.2.1.3 Miniature-tissue blocks
1.2.2 Feasibility of organ printing technology
1.2.3 In vivo behavior of 3D printed organ constructs
1.3 Advantages of 3D printing for medicine
1.3.1 Applications of 3D printing in medicine
1.3.1.1 3D printing for surgical templates and diagnostic tools
1.3.1.2 Organ printing technology
1.3.1.3 3D disease modeling
1.3.1.4 3D printing for commercial pharmaceutical products
1.3.2 Limitations and challenges of 3D printing
1.4 Future of 3D printing in medicine
2 3D printing families: laser, powder, nozzle based techniques
2.2 Classification of 3D printing techniques
2.2.1 Resin-based systems
2.2.2 Powder-based systems
2.2.3 Extrusion-based systems
2.2.4 Droplet-based systems
2.3 Conclusions and future trends
3 Materials for 3D printing in medicine: metals, polymers, ceramics, hydrogels
3.1.2 Biocompatibility of biomaterials
3.2.1 Conventional metals and their alloys
3.2.1.1 Titanium and its alloys
3.2.1.2 Stainless steel, other metals, and alloys
3.2.2 Shape memory alloys
3.2.3 Biodegradable metals
3.3 Bio-ceramics and bioactive glasses
3.3.1 Nondegradable bio-ceramics
3.3.2 Biodegradable and bioactive ceramics and glasses
3.5.1 Bioinks for 3D bioprinting
3.5.2 Natural polymer derived hydrogels
3.5.2.1 ECM derived hyrdogels
3.5.2.2 Nonmammalian sources derived polysaccharides
3.5.3 Synthetic polymer derived hydrogels
4 Computational analyses and 3D printed models: a combined approach for patient-specific studies
4.2 Patient specific models: image reconstruction
4.3 Patient specific models: 3D Manufacturing
4.4 Computer simulations of patient specific cardiac models
4.5 Patient specific models: the current regulatory perspective
4.6 Future perspective of patient specific models in cardiovascular applications
5 Patient specific in situ 3D printing
5.1 Patient specific 3D printing
5.1.1 Personalized medicine
5.1.2 Introduction to the technology: 3D printing in personalized medicine
5.1.3 Patient specific 3D model creation and design of tissue/organs
5.2 Current medical applications for 3D printing
5.2.1 3D bioprinting of organs and tissues
5.2.1.1 3D bioprinting in vitro
5.2.1.2 In situ 3D bioprinting directly to the defect/wound site
5.2.2 Patient specific medical devices: orthopedic devices, prosthetics, and implants
5.3 Challenges and future advances
6 3D printed in vitro disease models
6.2 Recent in vitro disease models
6.3 Challenges in developing in vitro disease models
6.4 3D printing technologies: strategies, key attributes, and advantages
6.4.1 Fabrication strategies/working principles
6.4.1.1 Laser-assisted bioprinting
6.4.1.2 Inkjet-based bioprinting
6.4.1.3 Extrusion-based bioprinting
6.4.3 How is 3D printing valuable for developing in vitro disease models?
7 3D printers for surgical practice
7.2 Imaging to printed model: steps involved
7.3 Limitations of CT and MRI images for surgical planning
7.4 3D printed models for anatomical simulation for surgeons
7.4.2 Heart valve surgery
7.5 Surgical planning of congenital anomalies
7.5.1 3D printing of surgical instruments
7.6 3D printed models for anatomical teaching
7.7 Tissue defect specific implant design
7.8 3D printing for surgical templates and diagnostic tools
7.9 Advantages of 3D printed models
7.10 Challenges for 3D printed models
7.11 Legal and ethical issues for 3D printing in surgery
8 3D printed pharmaceutical products
8.2 Pharmaceutical inkjet printing
8.3 Pharmaceutical 3D printing
8.3.1 Powder bed printing
8.3.2 Fused-filament printing
8.3.3 Stereolithographic printing
8.3.4 Selective laser sintering printing
9 High-resolution 3D printing for healthcare underpinned by small-scale fluidics
9.1 Clinical need and context
9.2 High-resolution 3D printing
9.2.1 Distinct features as opposed to photolithographic techniques
9.3 Types of high-resolution 3D printing
9.3.1 Direct-write printing
9.3.2 Electrohydrodynamic printing
9.3.3 3D Direct laser writing
9.4 Fundamentals of micro/nanofluidics
9.4.2 Ink properties: preliminary aspects of rheology
9.6 Exemplar functional devices
9.6.2 Site-specific deposition
9.6.4 Implantable devices
9.6.5 Printed bio-scaffolds
9.6.6 Mechanobiology and cell signaling studies
9.7 Conclusion and future directions
10 Four dimensional printing in healthcare
10.2 Nature inspired stimuli responsive materials for 4D printing
10.4 Stimuli responsive biomaterials for 4D bioprinting in medicine
10.5 Applications and examples of 4D printing in healthcare
3D Printing in Medicine
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