Chapter
2.3. Sirtuins: Regulators of Metabolism of Cancer and Aging
2.4. Nutrient-Sensing Pathways: A Common Signaling in Aging and Cancer
2.5. Inflammation and Cancer
3. Metabolic Interventions With Effects on Aging and Cancer
3.3. Fasting and Fasting-Mimicking Diet
3.4. Pharmacological Interventions Mimicking CR
3.4.1. Inhibitors of Nutrient-Sensing Pathways
3.4.2. Inhibitors of Glycolysis
3.4.3. Inhibitors of the GH/IGF-1 Axis
3.4.4. Activators of Sirtuins
3.4.5. Activators of AMPK Pathway
3.4.6. Inhibitors of Inflammation Pathways
4. Geroscience as a Strategy to Optimize Cancer Therapy
4.1. Fasting and Fasting-Mimicking Diet
4.3. Nutrient-Sensing Pathway Interventions
Chapter Two: Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis
2. The Phenomenon of Immune Tolerance
2.2. Peripheral Tolerance
2.2.1. B- and T-Cell Anergy
2.2.3. Immune Regulation/Suppression
2.2.3.1. Regulatory T Cells
2.2.4. Immune Privilege Sites
3. Factors That Influence the Loss of Immune Tolerance During Autoimmunity
3.1. Genetic Factors and Autoimmunity
3.2. Environmental Factors and Autoimmunity
3.2.1. Infection and Tissue Injury
3.2.2. Environmental Agents
4. Factors That Induce Autoimmunity
4.1. Epigenetics and Transcription Factors
4.1.1.1. Central Tolerance
4.1.1.2. Peripheral Tolerance
4.2. Extracellular Vesicles
4.2.1. The Source of Self-Antigens
4.2.2. Formation of Immune Complexes
4.2.3. Autoantigen Presentation
4.2.4. Inflammation and Immunity
4.3. Neutrophil Extracellular Traps
4.3.1. NETs in Autoimmune Diseases
4.3.1.1. Systemic Lupus Erythematosus
4.3.1.2. Rheumatoid Arthritis
4.3.1.3. ANCA-Associated Vasculitis
4.4.1. Role in Innate Immune Response and Autoimmunity
4.4.2. Role in Adaptive Immune Response and Autoimmunity
4.4.3. Antigen Presentation
5. Costimulatory and Coinhibitory Pathways in Autoimmunity
5.1. Costimulatory Pathways
5.2. Coinhibitory Pathways
6.1. PRRs and Autoimmunity
6.1.2. PRRs in Systemic Sclerosis
7. Tissue Inflammation and Injury in Autoimmunity
7.3. Monocytes and Macrophages
7.4. Tertiary Lymphoid Organs
8. Genetic Risk Factors for Organ Manifestations in Human Autoimmune Diseases
9.1. Systemic Autoimmunity in SLE
9.1.1. Apoptotic Material Triggers an Inappropriate Immune Response
9.1.2. Mistaking Self-Nuclear Components for Invading Virus
9.1.3. Directing Adaptive Immunity Against Autoantigens
9.2. Autoimmunity and Tissue Inflammation Inside the Kidney
9.2.1. Immune Complex Formation Inside the Kidney
9.2.2. Innate Immune Signaling Inside the Nephritic Kidney
9.2.3. Immune Cell Infiltration Into Renal Tissue
9.3. Animal Models for SLE
Chapter Three: Old and Novel Functions of Caspase-2
2.2. Tools for Monitoring Activity
3.2. Induced Proximity Activates Caspase-2 Within the PIDDosome
4. Caspase-2-Mediated Responses to DNA Damage and Mitotic Stress
4.1. DNA Damage-Induced Caspase-2 PIDDosome Formation
4.2. CHK1 Inhibition of PIDDosome Formation and Its Regulation by p53
4.3. Inconsistencies Regarding Outcomes of PIDDosome Signaling and Its Inhibition by CHK1
4.4. PIDDosome Inhibition by BubR1
4.5. An Alternative PIDD Complex Induces NF-κB
4.6. Phosphorylation in Prodomain or Linker Prevents Caspase-2 Activation
4.7. Caspase-2-Mediated Cell Cycle Arrest vs Apoptosis, Following DNA Damage or Mitotic Stress
4.8. Genomic Instability and Aneuploidy Due to Caspase-2 Inhibition
5. Responses to ER Stress
5.1. Brucella Infection-Mediated ER Stress
5.2. Rhabdovirus Infection-Mediated ER Stress
6. Relieving Oxidative Stress
6.2. Amelioration of Oxidative Stress
6.3. Suppression of Autophagy
6.4. Suppression of ROS-Driven Osteoclastogenesis
8.1. Mixed Messages From Human and Mouse Research
8.2. Promoting Neuroblastoma
9.2. Loss of Retinal Ganglion Cells Following Optic Nerve Injury
10. Neurological Conditions
10.1. Exacerbating Ischemic/Reperfusion Injury
10.3. Withdrawal of Nerve Growth Factor or Serum
10.4. Alzheimer´s Disease
10.5. Huntington´s and Motor Neuron Diseases
11.1. Why Has Caspase-2 Been Evolutionarily Conserved?
11.2. Manipulating Caspase-2 for Therapeutic Benefit
11.3. Could a Common Mechanism Underlie the Apparently Disparate Cellular Roles of Caspase-2?
11.4. Molecular Pathways Upstream and Downstream of Caspase-2
Chapter Four: Metabolic Reprogramming and Oncogenesis: One Hallmark, Many Organelles
2. Hallmarks of Metabolic Transformation in Cancer Cells
3. Compartmentalization of Metabolism
3.2. Endoplasmic Reticulum
4. Metabolic Cooperation Among Organelles
5. Challenges and Future Directions
Chapter Five: Molecular Biology Digest of Cell Mitophagy
1. Mitochondria Cannot Be Mended but Can Be Checked
2. Keeping the Engine Clean: Mitophagy
3. The Parkin-Dependent Way of Mitophagy
4. The Parkin-Independent Way of Mitophagy
Chapter Six: Regulation of Cell Calcium and Role of Plasma Membrane Calcium ATPases
4. Regulation of PMCA Pump
5. Role of PMCA Pump in Regulating Cell Ca2+
6. PMCA Pumps and Pathology
Chapter Seven: Emerging Mechanisms and Roles for Asymmetric Cytokinesis
2. Primer on Animal Cell Cytokinesis
2.1. Organization of Cytokinesis Contractile Ring
2.2. Regulation of Cytokinesis by Small GTPases Rho and Rac
2.3. Midbody Formation and Abscission
2.4. Overview of Epithelial Organization and Cytokinesis
3. Molecular and Cellular Mechanisms Controlling Asymmetric Cytokinesis
3.1. Intrinsic Regulation of Asymmetric Ring Constriction
3.2. Extrinsic Regulation of Epithelial Cytokinesis
3.2.1. Role of AJs in Asymmetric Ring Constriction
3.2.2. Remodeling of Cell Contacts at Daughter-Neighboring Cell Interface
3.3. Asymmetric Midbody Inheritance
4. Polarized Cytokinesis: Defining Cellular Identity and Shape
4.1. Importance of Midbody in Cell-Fate Determination
4.3. Midbody as Spatial Determinant of Epithelial Architecture
International Review of Cell and Molecular Biology
( Volume 332 )
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