Publisher: John Wiley & Sons Inc
E-ISSN: 1747-0285|91|2|631-640
ISSN: 1747-0277
Source: CHEMICAL BIOLOGY & DRUG DESIGN (ELECTRONIC), Vol.91, Iss.2, 2018-02, pp. : 631-640
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Abstract
The diverse pharmacological properties of the diaryltriazenes have sparked the interest to investigate their potential to be repurposed as antitubercular drug candidates. In an attempt to improve the antitubercular activity of a previously constructed diaryltriazene library, eight new halogenated nitroaromatic triazenides were synthesized and underwent biological evaluation. The potency of the series was confirmed against the Mycobacterium tuberculosis lab strain H37Ra, and for the most potent derivative, we observed a minimal inhibitory concentration of 0.85 μ
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