Antimicrobial and Cytotoxic Activity of Dihydrobenzofuran Neolignans

Publisher: John Wiley & Sons Inc

E-ISSN: 2365-6549|3|6|1836-1839

ISSN: 2365-6549

Source: ChemistrySelect, Vol.3, Iss.6, 2018-02, pp. : 1836-1839

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Abstract

AbstractWe have evaluated the antimicrobial activity of the dihydrobenzofuran neolignans (DBNs) 1 ((±)‐trans‐dehydrodicoumarate dimethyl ester), 2 ((±)‐trans‐dehydrodiferulate dimethyl ester, 3 ((±)‐4‐O‐acetyl‐trans‐dehydrodicoumarate dimethyl ester), and 4 ((±)‐4‐O‐acetyl‐trans‐dehydrodiferulate dimethyl ester) in terms of their minimum inhibitory concentration (MIC) values. We have also assessed the cytotoxicity of compounds 1–4 to V79 cells by the XTT assay. Compounds 1, 2, and 3 display moderate activity against Streptococcus mitis (MIC=400 μg/ml); compound 2 is also active against Lactobacillus casei (MIC=400 μg/ml). Additionally, compound 3 is moderately active against Aspergillus niger (MIC=125 μg/ml), A. fumigatus (MIC=500 μg/ml), and Mucor rouxii (MIC=250 μg/ml). Compounds 2 and 4 (IC50 > 400 μM), which have a methoxyl group at the aromatic ring, are less cytotoxic to V79 cells as compared to compounds 1 (IC50=232.00±7.33 μM) and 3 (IC50=67.97±3.45 μM).

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