

Publisher: John Wiley & Sons Inc
E-ISSN: 1614-7065|36|3|217-222
ISSN: 1001-604x
Source: CHINESE JOURNAL OF CHEMISTRY (ELECTRONIC), Vol.36, Iss.3, 2018-03, pp. : 217-222
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The first catalytic enantioselective C(sp)―C(sp3) cross‐coupling reaction between N‐tosylhydrazones and trialkylsilylethynes in the presence of Cu(I) salts and chiral phosphoramidite ligands was developed. A series of synthetically interesting, functionalized alkynes were obtained with moderate to good enantioselectivities (up to 83% ee). Cu(II) carbene migratory insertion is proposed to be the enantio‐determining step.
Related content










Cobalt‐Catalyzed Intermolecular C(sp2)O Cross‐Coupling
CHEMISTRY - A EUROPEAN JOURNAL, Vol. 21, Iss. 24, 2015-06 ,pp. :