Publisher： John Wiley & Sons Inc
E-ISSN： 1614-7065|36|3|217-222
ISSN： 1001-604x
Source： CHINESE JOURNAL OF CHEMISTRY (ELECTRONIC), Vol.36, Iss.3, 2018-03, pp. : 217-222
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Abstract
The first catalytic enantioselective C(sp)―C(sp3) cross‐coupling reaction between N‐tosylhydrazones and trialkylsilylethynes in the presence of Cu(I) salts and chiral phosphoramidite ligands was developed. A series of synthetically interesting, functionalized alkynes were obtained with moderate to good enantioselectivities (up to 83% ee). Cu(II) carbene migratory insertion is proposed to be the enantio‐determining step.
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