Aqueous Chloroplatinic Acid: A Green, Chemoselective and Reusable Catalyst for the Deprotection of Acetals, Ketals, Dioxolanes and Oxathiolanes

Publisher： John Wiley & Sons Inc

E-ISSN： 2365-6549|3|7|1999-2003

ISSN： 2365-6549

Source： ChemistrySelect, Vol.3, Iss.7, 2018-02, pp. : 1999-2003

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Abstract

AbstractAqueous chloroplatinic acid (H2PtCl6) as an effective catalyst for the deprotection of acetals, ketals, 1,3‐dioxolanes and 1,3‐oxathiolanes to the corresponding carbonyl compounds in 56–99% yield has been reported. In addition, the catalyst has high‐selectivity in cleaving vicinol diol protection, yielding mono‐protected diols from di‐protected diols as a product. The present deprotection method is novel, chemoselective and offers broad functional group tolerance with short reaction time. Besides, the reaction protocol can be accomplished at ambient temperature and the catalyst is reusable.

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