Distal Functional Group Migration for Visible‐light Induced Carbo‐difluoroalkylation/monofluoroalkylation of Unactivated Alkenes

Publisher： John Wiley & Sons Inc

E-ISSN： 1615-4169|360|4|744-750

ISSN： 1615-4150

Source： ADVANCED SYNTHESIS & CATALYSIS, Vol.360, Iss.4, 2018-02, pp. : 744-750

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Abstract

AbstractA general and practical protocol for elusive carbo‐difluoroalkylation/ monofluoroalkylation of unactivated alkenes based on the distal functional group migration is described. A portfolio of functional groups including heteroaryl, imino, formyl, and alkynyl groups showcase the migratory aptitude. In combination with visible‐light photocatalysis, a broad range of di‐ and mono‐fluorinated alkyl ketones are readily obtained in synthetically useful yields under mild reaction conditions.

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