Cytokine-adjuvanted HIV-DNA vaccination strategies

Author: Lori Franco   Weiner David   Calarota Sandra   Kelly Laurene   Lisziewicz Julianna  

Publisher: Springer Publishing Company

ISSN: 0344-4325

Source: Springer Seminars in Immunopathology, Vol.28, Iss.3, 2006-11, pp. : 231-238

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Abstract

This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.