Author： Ernst Jan-Peter
Publisher： Springer Publishing Company
ISSN： 1617-6782
Source： Zeitschrift für Epileptologie, Vol.21, Iss.1, 2008-03, pp. : 26-29
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Abstract
West and Lennox-Gastaut syndromes are age-dependent epileptic disorders mostly caused by brain malformation or brain lesion. Main manifestation ages are 6-12 months and 2-5 years, respectively. Ictal semiology and electrographic patterns are highly characteristic. Both syndromes prove as refractory concerning pharmacotherapy; few cases, mostly idiopathic or crytogenic, respond to antiepileptic drugs. The long-term course is poor in most cases and marked by a profound neuropsychiatric deficit and persistent severe focal seizures. Only 10% of all patients have reached a satisfactory level of quality of life.
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