Author： Katzenstein H.M.
Publisher： Adis International
ISSN： 1175-6357
Source： American Journal of Cancer, Vol.2, Iss.4, 2003-01, pp. : 237-244
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Neuroblastoma (NB), a common pediatric neoplasm arising from neural crest cells, is characterized by a diversity of clinical behavior ranging from spontaneous remission to rapid tumor progression and death. Biologic and genetic factors have been identified which, to a certain extent, can predict prognosis and guide risk-based therapy. Recent research has focused on the role of angiogenesis in NB tumor biology and in determining clinical phenotype. Preclinical studies have explored the efficacy of antiangiogenic therapies as a novel treatment modality for children with NB. This review discusses the current understanding of angiogenesis in NB, the clinical implications, and future directions for antiangiogenic therapeutic strategies in NB.
Related content
Angiogenesis and anti-angiogenesis in neuroblastoma
By Ribatti D. Vacca A. Nico B. De Falco G. Giuseppe Montaldo P. Ponzoni M.
European Journal of Cancer, Vol. 38, Iss. 6, 2002-01 ,pp. :
Access to resources
Recommend
Inhibition of Angiogenesis as a Treatment Strategy for Neuroblastoma
Current Cancer Therapy Reviews, Vol. 13, Iss. 1, 2017-08 ,pp. :
Access to resources
Clinical imaging of tumor angiogenesis
By Patel Neel Harris Adrian L Gleeson Fergus V Vallis Katherine A
Future Oncology, Vol. 8, Iss. 11, 2012-11 ,pp. :