Author： Sriram Dharmarajan Yogeeswari Perumal Thirumurugan Rathinasabapathy Ratan Bal Tanushree
Publisher： Taylor & Francis Ltd
ISSN： 1478-6419
Source： Natural Product Research, Vol.19, Iss.4, 2005-06, pp. : 393-412
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Abstract
Topoisomerase I (Topo-I) is a major target for anticancer drug discovery and design. As a result, Topo-I inhibitors constitute an important class of the current anticancer drugs. To date, all of the Topo-I inhibitors that have been clinically evaluated are analogues of camptothecin (CPT), an extract of the Chinese tree Camptotheca acuminata . CPT has shown significant antitumor activity to lung, ovarian, breast, pancreas and stomach cancers. In this article the, phytochemical aspect, and various structural modifications are comprehensively reviewed as in rings A, B, C, D and E. Biological activity of camptothecin, other than anticancer, reported till the year 2003 has also been discussed.
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