Prenylated 2-arylbenzofurans from Artocarpus petelotii

Author: Shen Hong   Hou Ai-Jun  

Publisher: Taylor & Francis Ltd

ISSN: 1478-6419

Source: Natural Product Research, Vol.22, Iss.16, 2008-11, pp. : 1451-1456

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Abstract

Further phytochemical investigation on the root barks of Artocarpus petelotii Gagnep afforded two new prenylated 2-arylbenzofurans, artopetelins L and M (1 and 2), as well as a known compound, lakoochin B (3). Their structures were identified by spectroscopic methods. Artopetelins B-E (5-8), four 2-arylbenzofurans previously isolated from this plant, and lakoochin B (3) were potent against HepG2 (IC50 = 14.4-44.4 µM) and MCF-7 (IC50 = 29.7-59.1 µM).