Author： Jiang Pingping
Publisher： Springer Publishing Company
ISSN： 0928-0707
Source： Journal of Sol-Gel Science and Technology, Vol.61, Iss.2, 2012-02, pp. : 421-428
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Abstract
Hierarchical porous TiO2-bioglasses (TiO2-BGs) with the macropore with the size of 30-50 μm and the mesopore with the diameter of 4.4-5.6 nm have been synthesized through the evaporation-induced self-assembly method. The corn stalks were used as the macroporous template and P123 as the mesoporous template in the process. The chemical and physical properties of the hierarchical porous TiO2-BGs before and after immersion in simulated fluid (SBF) were evaluated by X-ray diffraction, scanning electron microscope, Fourier transform infrared spectroscopy, nitrogen adsorption-desorption, and Energy dispersive spectrometer. The effect of TiO2 content on the formation of surface hydroxyapatite and drug release profiles of the fabricated TiO2-BGs in SBF were investigated in detail. It was found that macroporous-mesoporous TiO2-bioglasses (MM TiO2-BGs) exhibited a good ability of surface hydroxyapatite formation comparing with macroporous-mesoporous bioglasses. It took only 3 h for the MM TiO2-BGs to be covered with the hydroxyapatite layer. It can be ascribed to the present of Ti-OH which may improve the spontaneous growth of apatite by consuming the calcium and phosphate ions from SBF. Additionally, MM TiO2-BGs also showed good drug sustained release profiles. Therefore, the multifunctional MM TiO2-BGs reported here could be a good candidate for application in bone tissue engineering.
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