Author： Mayr B.
Publisher： Springer Publishing Company
ISSN： 0165-7380
Source： Veterinary Research Communications, Vol.23, Iss.5, 1999-08, pp. : 285-291
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Abstract
Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC→AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGC→CAC (arginine→histidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The somatic nature of the three mutations was demonstrated.
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